Discontinue interfering drugs for at least 5 half-lives ahead of administration of possibly the dosimetry or an iobenguane dose. Will not administer these medications right until at the very least seven times just after Every iobenguane dose.
For oral dosage variety (tablets): For narcolepsy or obstructive sleep apnea/hypopnea syndrome: Grownups and youngsters seventeen decades of age and more mature—two hundred milligrams (mg) at the time each day, in the morning. Your medical doctor may boost your dose as essential. Adolescents and youngsters youthful than seventeen several years of age—Use and dose need to be based on your physician.
Small (one)modafinil will raise the degree or impact of rabeprazole by affecting hepatic enzyme CYP2C19 metabolism. Insignificant/Importance Mysterious. Web effect on pantoprazole steps unidentified because of opposing outcomes of CYP450 enzymes; keep an eye on
indinavir will raise the degree or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Suicidal views or actions may be brought on by issues other than medicines. When you have suicidal feelings or actions, your healthcare service provider might look for other causes. Concentrate to any changes In particular sudden alterations in temper, behaviors, feelings, or emotions and keep all abide by-up visits using your Health care supplier as scheduled. Contact your Health care supplier concerning visits as wanted, particularly if you might be worried about indications. Don't cease FYCOMPA devoid of first conversing along with your Health care service provider.
Most of the documented conditions have occurred in 6 weeks of drug initiation. For that reason, any affected individual who develops a rash for the duration of this time period is advised to notify the prescribing medical professional promptly.[21]
eslicarbazepine acetate will improve the stage or influence of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor.
Evaluation Modafinil : a review of its use in excessive sleepiness associated with obstructive sleep apnoea/hypopnoea syndrome and change do the job slumber dysfunction.[CNS Medicine. 2005]
stiripentol will increase the level or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Consider reducing the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.
No sizeable changes in entire body fat are noticed in scientific trials, although reduced hunger and weight reduction have already been famous in little ones and adolescents.
dizziness; sleepiness; tiredness; irritability; website falls; nausea and vomiting; weight achieve; vertigo (feeling of spinning); challenges walking Typically; issues with muscle mass coordination; headache; bruising; abdominal ache; stress and anxiety FYCOMPA is really a managed compound (CIII) because it is usually abused or bring on drug dependence.
rifapentine will minimize the extent or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
rifampin will decrease the extent or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
On top of that, a number of intentional acute overdoses occurred; The 2 most significant becoming 4500 mg and 4000 mg taken by two subjects taking part in foreign melancholy experiments. None of these research subjects seasoned any unpredicted or everyday living-threatening effects. Adverse reactions that were reported at these doses integrated excitation or agitation, insomnia, and slight or moderate elevations in hemodynamic parameters.